Lack of sleep will weaken your immune system. Even one night of sleep can harm your immune system and cells that try hard to fight off diseases. During deep sleep, the immune system strengthens itself and fights infection. Therefore, sleep deprivation comprises with the immune system and makes the body susceptible to colds and flu. Also, lack of sleep makes it hard for you to shake off the flu after you get it. In addition, sleep restrictions in people resulted significant changes in metabolic and endocrine functions. Glucose tolerance decreased, evening cortisol concentrations increased, and the activity of the nervous system was also increased.
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